Category Archives: Autism Research

Comprehensive Autism Workforce Development Initiative

An integral component of ICare4Autism’s Global Autism Center for Research and Education in Jerusalem will be the world’s first comprehensive autism workforce development initiative which will encompass workforce entry services for high school students with autism, post-transition supportive services, vocational and employment services ranging from semi-skilled to high functioning individuals, and a special targeted program to place persons with Asperger’s Syndrome in technology sector jobs.

Workforce Entry Services

Services to provide high school students with autism with the opportunity to discover their interests and abilities by participating in a variety of vocational experiences, and works with students and their families to develop realistic transition plans when preparing to leave school and enter the workforce.  Also includes post-transition supportive services and independent life skills reinforcement.

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The Difference Between Autism and Social Anxiety

A quick google search reveals that there are many people trawling web forums wanting to find out if there is a difference between high functioning autism and social anxiety.  Some sites list it as one of their most frequently asked questions and the answer is always the same: autism and social anxiety are two very different things.

It is easy to understand why the two are often confused as they have many symptoms in common.  People with these conditions can be shy, avoid eye contact, be awkward in social situations and have bad communication skills.

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Chromosome Abnormality Tied to Autistic Behavior in Mice

chromosomeFrom Schafer, Finding could help advance autism research in humans is.gd/1gbJ4 HealthDay News — Mice with an extra chromosome region inherited from their fathers display many behaviors seen in people with autism, a finding that suggests that the same chromosome abnormality in humans is one cause of autism, according to Japanese scientists. The mice will be an important tool in efforts to develop treatments for autism, the researchers from Hiroshima University say. Their report appears in the June 26 issue of the journal Cell.

The duplicated chromosomal region in mice is the equivalent of human chromosome 15q11-13, which is duplicated in about 5 percent of all people with autism. It is believed that chromosomal abnormalities account for 10 to 20 percent of autism cases, according to a news release from the journal’s publisher, Cell Press. So far, duplication of chromosome 15q11-13 is the only recurrent aberration connected to autism. The mice with an inherited duplication of a region on their chromosome 7 showed autism-like behaviors, such as poor social interaction, behavioral inflexibility, abnormal vocalizations and anxiety, the researchers found.

“The link between social behaviors in rodents and social behavior in humans is difficult to establish,” the study authors concluded. “Our model mouse will be valuable not only for therapeutic studies but also provides a starting point for more detailed genetic analysis directed toward understanding the etiology of developmental brain disorders.”

Treating Autism with Special Diets

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Treating Autism with Special Diets

Amy Eisenbeisz, RD, LN, and Marcie Kemnitz, MS, RD, LN

Does following a certain diet or eliminating certain foods from a child’s diet help treat autism symptoms? This is a common question that parents of children with Autism Spectrum Disorders (ASD) ask. Unfortunately, there is no easy answer to this question.  Several studies show some improvement with these various diets, while other studies show minimal effect.  We put together information on the three most common diets used for treating ASD symptoms to help you better understand them.

Elimination Diet
This diet is used to determine if a child has a potential allergy to certain foods by starting with a very basic diet low in potential allergenic foods and then gradually adding back in these foods to see what type of reaction occurs.  We might expect to see an allergic reaction such as hives or runny nose or we might see gastrointestinal symptoms such as diarrhea or constipation.

These foods tend to be responsible for 90% of all allergic reactions:  milk*, wheat*, egg*, soy*, peanuts*, tree nuts*, fish and shellfish (*more commonly seen in children).  There are multiple tests for food allergies including blood and skin prick tests.  However, there may be false negatives or positives with these tests.  The ELISA test is sometimes recommended, but it is not a validated food allergy test and many not indicate accurate results.

We know that, according to Elizabeth Strickland, children with food allergies are at a higher risk for nutrition related problems and decreased growth.  Also, children with autism are more likely to be more negatively affected by problems with food allergies because of their issues with sensory dysfunction.

Gluten Free/Casein Free (GF/CF Diet)

With this diet, the child must avoid all sources of gluten (the protein found in wheat-based foods) and casein (the protein found in milk and dairy foods).  There are two theories as to why this diet might work:
1. The protein found in gluten and casein may cause disruption in normal brain activity resulting in the symptoms seen in autism.
2. These same proteins may cause an inflammatory response resulting in the symptoms seen in autism. While this diet is considered to be experimental, many families have found a positive response to the diet. This response is more commonly seen in younger children.  Reichelt recommends trying this diet for a minimum of three months to see the full benefit.  However, to see the benefit of this diet, strict adherence is required.  Adherence is often difficult because of the complexity of the diet, and even minute amounts of gluten or casein will affect the outcome and you may not see any benefit.  The diet has to be followed
at home, school, and wherever the child eats.  Even eating a small graham cracker (which contains gluten) could throw off the outcome of this diet.

Specific Carbohydrate Diet (SCD)

This diet is considered the last resort and is not commonly used.  It is based on a belief that certain carbohydrates can cause gastrointestinal (GI) inflammation, which causes pain and discomfort.  By removing these carbohydrates (mainly lactose, sucrose and maltose), these symptoms are lessened and the bowel can heal.

Should this diet be recommended?  Current studies show that many children with autism have a lot of GI problems and a child presenting with these problems should be referred to a gastroenterologist for an appropriate diagnosis before starting this restrictive diet.

Problems with the above diets
• These diets are quite restrictive in terms of the types and categories of foods that need to be avoided; therefore, if not done correctly, a child can become deficient in many nutrients such as protein, B- complex vitamins, iron, and calcium.  We recommend visiting with a registered dietitian before beginning any of these to receive guidance as to how to follow these properly.

• Foods required by the diets can be quite expensive.  For example, a normal brownie mix costs around $2.00, but a GF/CF brownie mix is going to cost about $4.00-$5.00.  Generally, most GF/CF foods will cost 50%-100% more than their regular counterpart.

• Strict adherence to these particular diets is required.  Often it is difficult for families to adhere to the diet for the three months required to see any benefit.  Many parents think that they don’t have to follow the diet every day or all day and eventually give in and allow their child to eat foods not allowed on the diet.  This is especially noted in families where other siblings are eating regular food items.

Recommendations
While many of these diets might seem to be the answer to helping deal with the aspects of autism, they are rather difficult to follow and can be expensive.  Several studies have shown that these diets may improve ASD symptoms, but the overall results are inconclusive.  We recommend visiting with a registered dietitian and getting a full nutritional assessment of the child before starting any diet changes or modification.

If you have questions about the above information, please feel free to contact us at 800-658-3080 and we
would be glad to answer your questions.

References:
Strickland, Elizabeth; Nutrition Therapy for Children with Autism Spectrum Disorder, Autism, Asperger’s, PDD, and Other Related Disorders, 2005.

Reichelt K. et al.  Gluten, milk proteins and autism: Dietary intervention effects on behavior and peptide secretion.  J Appl Nutr, 1990; 42:1-11.

People with Autism Better at Problem-Solving

problem solvingFrom The News-Medical.net, Autistics are up to 40 percent faster at problem-solving than non-autistics, according to a new Université de Montréal and Harvard University study published in the journal Human Brain Mapping.

As part of the investigation, participants were asked to complete patterns in the Raven’s Standard Progressive Matrices (RSPM) – test that measures hypothesis-testing, problem-solving and learning skills.

“While both groups performed RSPM test with equal accuracy, the autistic group responded more quickly and appeared to use perceptual regions of the brain to accelerate problem-solving,” says lead author Isabelle Soulières, a post-doctoral fellow at Harvard University who completed the experiment at the Université de Montréal. “Some critics agued that autistics would be unable to complete the RSPM because of its complexity, yet our study shows autistics complete it as efficiently and have a more highly developed perception than non-autistics.”

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Canadian Program Monitors Language Acquisition in Autistic Youth

An important article on Medical News Today discusses the Language Use Inventory (LUI) project, a parent questionaire that helps evauluate language acquisition patterns in children with autisim.

The program was created by a developmental psychologist out of Canada’s University of Waterloo, Daniella O’Neill.  According to O’Neill:

The LUI looks at pragmatic language development which has do with how young children are able to use their language effectively and successfully in everyday interactions with other people in ways that are age-appropriate and typical. For example, to ask for help, comment about noticeable things, tease, tell stories and give others information they might need. The pragmatics of language can be an area of great difficulty for children with autism.

A parent has had the most experience watching their child try to use their language in a host of different settings and with many different people.

Akin to height and weight charts used by doctors, the LUI will allow parents a barometer to measure the development of their children.  The LUI tracks autistic children and their peers at all levels, facilitating an impressive data set that does not presently exist.

First Signs of Autism Could be Detected In the Brain

Amygdala

Amygdala

Researchers at the University of North Carolina used MRI brain scans to look at the area of the brain called the amygdala, which was on average 13 percent larger in young children with autism. The amygdala helps individuals process faces and emotions. The size of this specific part of the brain and may help experts pinpoint when autism could first develop.

“We believe that children with autism have normal-sized brains at birth but at some point, in the latter part of the first year of life, it [the amygdala] begins to grow in kids with autism. And this study gives us insight inside the underlying brain mechanism so we can design more rational interventions,” said lead study author Dr. Joseph Piven.

“Once we understand the neurological circuits, we may be able to detect if a child has problems in those circuits as early as 6 months of age,” said Piven. “If we are able to combine those things, we can better predict and guide interventions. We need to let the pattern of early brain development guide us to predict who is at higher risk and who would benefit from early intervention.”

Dr. Joseph Piven will be a key speaker key speaker at 2010 International Autism Conference in Jerusalem, Israel. The conference, titled “Autism: A Global Problem,” will be held the week of February 17 to 19 at the ICC.

Autism experts say such findings are critical in developing new ways to treat and diagnose autism earlier. The study was published in the latest Archives of General Psychiatry and to watch a video of the findings, click here.

Scientists Reaching Consensus On How Brain Processes Speech

How the Brain Processes Speech

How the Brain Processes Speech

From ScienceDaily, Neuroscientists feel they are much closer to an accepted unified theory about how the brain processes speech and language, according to a scientist at Georgetown University Medical Center who first laid the concepts a decade ago and who has now published a review article confirming the theory.

In the June issue of Nature Neuroscience, the investigator, Josef Rauschecker, PhD, and his co-author, Sophie Scott, PhD, a neuroscientist at University College, London, say that both human and non-human primate studies have confirmed that speech, one important facet of language, is processed in the brain along two parallel pathways, each of which run from lower- to higher-functioning neural regions.

These pathways are dubbed the “what” and “where” streams and are roughly analogous to how the brain processes sight, but are located in different regions, says Rauschecker, a professor in the department of physiology and biophysics and a member of the Georgetown Institute for Cognitive and Computational Sciences.

To view full article, click here.

Cambridgeshire Study Confirms 1 Per Cent Prevalence Of Autism

Autism 1 Percent

Autism 1 Percent

From Medical News Today, A new study has confirmed that 1 per cent of children aged between 5- and 9-years-old have an existing diagnosis on the autistic spectrum. The research, published in the June issue of the British Journal of Psychiatry, was carried out by the Autism Research Centre at Cambridge University. The research team, led by Professor Simon Baron-Cohen, used three different methods to estimate the prevalence of autism-spectrum conditions (including previously undiagnosed cases) in Cambridgeshire.

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European Union Research Grant Awarded To University Of Haifa Research Team

Haifa Research Team Awarded Grant

Haifa Research Team Awarded Grant

From Medical News Today, The research team is headed by Prof. Kobi Rosenblum of the University of Haifa’s Department of Neurobiology and Ethology and has been awarded a grant of $815,000. A research team composed of 14 European groups, headed by Prof. Nils Brose of the Max Planck Institute for Experimental Medicine, has been awarded 11.9 million Euro, on behalf of the European Union, to study the role of synaptic proteins in neurological and psychiatric diseases. One of the research teams is headed by Prof. Kobi Rosenblum of the University of Haifa’s Department of Neurobiology and Ethology and has been awarded a grant of 600,000 Euro. The topic of the grant is “Synaptic protein networks in neurological and psychiatric disease.”

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